GHK-Cu
Glycyl-L-Histidyl-L-Lysine Copper Complex · Naturally Occurring Tripeptide · Research Use Only
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Plasma levels peak around 200 ng/mL at age 20 and decline 60% by age 60 — mirroring the decline in skin elasticity, wound healing speed, and tissue repair capacity. It has 50 years of research behind it and influences over 4,000 human genes, making it one of the most broad-acting biological regulators in peptide science.
How it works: GHK-Cu acts as a copper delivery vehicle, transporting Cu2+ ions to over 30 enzyme systems including lysyl oxidase (collagen cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial energy). It stimulates collagen I, III, elastin, and glycosaminoglycan synthesis while regulating metalloproteinases (MMPs) to drive organized matrix remodeling. Broad Institute Connectivity Map analysis shows it activates DNA repair genes and collagen synthesis genes while suppressing inflammatory mediators.
Research highlights:
- Human clinical trial: GHK-Cu improved collagen in 70% of women — outperforming vitamin C cream (50%) and retinoic acid (40%)
- Yuvan Research IRB trial: 28% average collagen density increase after 3 months; top quartile saw 51% increase
- Broad Institute: GHK-Cu affects 31.2% of human genes when 50%+ change criterion applied
- Wound models: 9x increase in collagen synthesis vs control
Molecular Formula: C₁₄H₂₄CuN₆O₄
Molecular Weight: 403.9 g/mol
Form: Lyophilized powder
Purity: ≥98% (HPLC verified)
Storage: -20°C, away from light and moisture
⚠ RESEARCH USE ONLY. This product is intended for laboratory and in vitro research purposes only. Not for human or animal consumption. Must be 21+ to purchase. These statements have not been evaluated by the FDA.